Macrolides and analogues
Apexbio Technology LLC (5Z)-7-Oxozeaenol(Synonyms: (5Z)-7-Oxozeaenol, 7-Oxozeaenol, TAK1 inhibitor, MAPKKK inhibitor), 1mg, CAS: 253863-19-3.
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models
Medchemexpress LLC Epothilone F | 208518-52-9 | 99.0% | 10 MG
Epothilone F is a 16-membered macrolide microtubule-targeting agent. It exhibits significant anticancer activity and is particularly effective against paclitaxel-resistant cancer cells. This compound inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells, making it widely used in cancer-related research.
- Functions as a microtubule-targeting agent.
- Demonstrates significant anticancer activity.
- Effective against paclitaxel-resistant cancer cells.
- Inhibits proliferation of breast, non-small cell lung, and drug-resistant ovarian cancer cells.
- Widely used in cancer-related research.
- Exhibits cytotoxicity against mouse L929 cells with an IC50 of 1.5 ng/mL.
Cayman Chemical 5Z 2E-CU-3 10mg
A DGK-α inhibitor (IC50 = 0.6 µM for the porcine enzyme); selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM); induces apoptosis in HeLa and HepG2 cells and enhances concanavalin A-induced increases in IL2 mRNA expression in Jurkat T cells at 5 µM
Medchemexpress LLC Zearalenone | 17924-92-4 | MFCD00133085 | 98.9% | 318.36 g/mol | C18H22O5 | 25 MG
Zearalenone is a nonsteroidal estrogenic mycotoxin provided as an analytical standard for research and analytical applications, including method development, calibration, and mycotoxin screening.
- Purity: 98.9%.
- CAS number: 17924-92-4.
- Molecular formula: C18H22O5; molecular weight: 318.36 g/mol.
- Appearance: white to off-white solid.
- Pack size: 25 mg vial.
- Storage: store under nitrogen; in solvent, -80°C (1 year) or -20°C (6 months).
- Applications: analytical standard for mycotoxin detection, method development, and calibration.
Medchemexpress LLC Zearalenone | 17924-92-4 | MFCD00133085 | 98.9% | 318.36 | C18H22O5 | 100 MG
Zearalenone is a Fusarium-derived mycotoxin with estrogenic activity used as a research standard and analytical reference for toxicology, food safety, and assay development.
- High purity 98.85% suitable for analytical applications.
- Molecular formula C18H22O5 and molecular weight 318.36.
- Available as solid (including 100 MG) and as a 10 mM solution in DMSO.
- Appropriate for assay development, method validation, and toxicology studies.
- Stable under recommended storage and handling conditions when used as a reference standard.
Medchemexpress LLC Epothilone B | 152044-54-7 | 99.9% | 507.68 | 1 ML
Epothilone B is a microtubule stabilizer (MSA) with a Ki of 0.71μM and possesses blood-brain barrier permeability. It functions by binding to the αβ-tubulin heterodimer subunit, which leads to a decrease in αβ-tubulin dissociation. It is intended for research use only and is not sold to patients.
- Microtubule stabilizer (MSA)
- Blood-brain barrier permeability
- Binds to the αβ-tubulin heterodimer subunit
- Decreases αβ-tubulin dissociation
Abcam Epothilone B, Microtubule stabilizing agent, 10UG
MW 507.7 Da, Purity >98%. Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
![eMolecules 363-24-6 | (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid | Key Organics/BIONET | MFCD00077861 | 352.471 | C20H32O5 | 97.000 | CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O | 1mg | 601475532](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000127981.jpg-250.jpg)
eMolecules 363-24-6 | (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid | Key Organics/BIONET | MFCD00077861 | 352.471 | C20H32O5 | 97.000 | CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O | 1mg | 601475532
(5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid | Key Organics/BIONET | 363-24-6 | MFCD00077861 | 352.471 | C20H32O5 | 97.000 | CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O | 1mg | 601475532
TARGETMOL CHEMICALS INC ZEARALENONE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Zearalenone (F2 toxin) is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in cattle pigs and sheep with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts. purity: 99%
Apexbio Technology LLC Zearalenone(Synonyms: F-2 toxin, Mycotoxin F2, Zearalenolactone, RAL, ZEA, Zenon), 10mg, CAS: 17924-92-4.
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Medchemexpress LLC Zearalenone (standard) | 17924-92-4 | MFCD00133085 | 98.9% | 318.36 g/mol | C18H22O5 | 25 MG
Zearalenone (standard) is an analytical reference standard of the mycotoxin zearalenone (CAS 17924-92-4) supplied as a solid for analytical and research use. It is intended for qualitative and quantitative method development and testing by HPLC, GC, and MS, and is supplied at high purity for reliable analytical performance.
- Analytical standard for HPLC, GC, and MS.
- High purity (≈98.9%) for reliable quantitation.
- Solid form for easy storage and handling.
- Suitable for qualitative and quantitative method development.
- Includes certificate of analysis for quality verification.
Medchemexpress LLC Epothilone F | 208518-52-9 | 99.5% | 50 MG
Epothilone F is a 16-membered macrolide microtubule-targeting agent. It shows significant anticancer activity, particularly effective against paclitaxel-resistant cancer cells. It inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells, and is used in cancer-related research.
- Microtubule-targeting agent
- Exhibits significant anticancer activity
- Effective against paclitaxel-resistant cancer cells
- Inhibits proliferation of breast cancer cells
- Inhibits proliferation of non-small cell lung cancer cells
- Inhibits proliferation of drug-resistant ovarian cancer cells
- Used in cancer-related research